Four kinds of people end up here. If one of them is you, this formula was built for you.
Cravings + crashes
A sugar craving 20 minutes after lunch, grazing until dinner, and an appetite that always gets the last word.
Sugaheal® and dihydroberberine steady the post-meal glucose swing. Live Akkermansia works the gut side of the fullness signal. Cravings lose their fuel from both ends.
More than berberine
Huge pills, an unhappy stomach, and partial results from one commodity ingredient at a dose nobody would print.
Berberine covers one pathway. This adds the patented alternative (Sugaheal®), the form up to 5x more bioavailable (dihydroberberine), live Akkermansia and the prebiotic fuel it needs.
PCOS, perimenopause, 40+
Numbers that drift, a belly that won’t budge, and cravings that feel chemical, not optional.
Six actives across three pathways: post-meal glucose metabolism, gut GLP-1 signaling, and the prebiotic fuel behind it.
Shot-curious
The needle, the prescription, the side-effect stories, and a bill around $1,000 a month.
Nature’s GLP-1 activates your body’s own GLP-1 pathway instead: two capsules, $1.50 a day, every dose printed on the label so you can check it yourself.
GLP-1 support compounds. Here is what to watch for, and when.
Live Akkermansia and its prebiotic fuel go to work. Watch for less bloating and the first after-lunch sugar craving that simply doesn’t show up.
The afternoon crash softens. You feel full on less, without white-knuckling it. Post-meal energy holds. The snack drawer stops calling your name.
A quiet appetite between meals becomes the normal day, not the good day. This is where consistency starts paying you back.
Predictable energy, a calmer appetite, and a two-capsule habit that runs itself. Day 90 is also where your guarantee window closes, so you judge it on the full arc.
The Berberine Upgrade
Most “GLP-1” supplements are repackaged commodity berberine at a dose they won’t print. Huge pills, upset stomachs, one pathway. CLADETM leads with 410mg of patented Sugaheal®, clinically studied for healthy glucose metabolism and working through its own pathway without the GI issues of high-dose standalone berberine. Then it adds 20mg of Dihydro Berberine, the form up to 5x more bioavailable than standard berberine. Two mechanisms, both doses printed on the label.
The Gut-GLP-1 Axis
Your GLP-1 is made in your gut, by L-cells in the intestinal lining. Akkermansia muciniphila, a keystone gut bacterium clinically studied for its role in GLP-1 signaling and metabolic health, talks directly to those cells. Most GLP-1 formulas leave it out. We put it in live, with its fuel: Chicory helps it establish and hold its ground in your gut, with Beta Glucan providing additional prebiotic support. Standardized Vinomerix Optima® (16% Monomers & 80% OPCs from grape seed) adds the grape polyphenols that increased Akkermansia in published animal research. The bacteria, its fuel, and its growth promoter, in the same two capsules.
Full Formula Disclosure
Most metabolic supplements hide behind "GLP-1 Support Blend 800mg" with no breakdown. You have no idea how much Akkermansia or how little berberine you're actually paying for. That is how fairy dust gets sold at $80 a bottle. CLADETM prints every dose on the bottle. One patented extract (Sugaheal®) alongside standardized Vinomerix Optima®. Six clinically studied ingredients. 1,150mg of active compounds per serving. Zero guesswork.
Patricia W.
Steadier energy
"Steadier energy, fewer crashes"
I tried berberine for six months with barely any change. Two months on CLADETM, my afternoon energy stopped crashing and the constant snack cravings finally eased off. When I compared the label to the research, the Sugaheal dose lined up. Staying on this.
Karen S.
Label reader
"The only GLP-1 supplement I trust"
I read labels obsessively and I'm skeptical of every GLP-1 supplement out there. Most are berberine with a new label. CLADETM lists Akkermansia and Vinomerix at specific doses I can verify against published research. That's why it's the one I stuck with.
Danielle R.
Cravings relief
"The cravings went quiet"
By week three, I stopped reaching for something sweet after every meal. By month two, the afternoon energy crash was gone. I've tried berberine, chromium, apple cider vinegar supplements. This is the first time something actually shifted how my body handles sugar after meals.
Michael T.
Age 55
"Energy that holds through the afternoon"
I wanted something I could actually understand, every dose printed, nothing hidden in a blend. After three months of consistent use, my afternoon energy holds and the between-meal snacking has dropped off. The transparency is what won me over.
Christine B.
Age 47
"Cravings faded, energy came back"
It took about four weeks to really feel it. But once my digestion normalized and the sugar cravings faded, I was sold. Five months in now and steady afternoon energy is just my normal. I notice immediately when I skip a day.
Jennifer A.
Age 42
"Berberine alone wasn't enough"
I was taking 1000mg of generic berberine daily and still dealing with afternoon crashes and constant cravings. Switching to CLADETM, the combination of Sugaheal with the Akkermansia gut support made a noticeable difference within a month. The multi-pathway approach just made more sense to me.
Lead actives at the levels published research uses. Supporting doses where the job is support. No underdosing to cut costs. No megadosing to pad a label.
Six ingredients, three pathways, one job: put your own GLP-1 signal back to work.
The patented alternative to commodity berberine, clinically studied for healthy glucose metabolism. Unlike commodity berberine with variable potency, Sugaheal is standardized and dosed at the level used in published clinical research. Sugaheal supports glucose metabolism through a separate metabolic pathway, without the GI issues associated with high-dose standalone berberine. Paired with a small 20mg supporting dose of Dihydro Berberine for complementary metabolic pathway coverage.
The upgraded form of berberine, up to 5x more bioavailable than standard berberine. At a 20mg supporting dose, it complements Sugaheal through a separate metabolic pathway, without the GI discomfort associated with high-dose standalone berberine.
The keystone gut bacterium, roughly 1-4% of a healthy gut microbiota. Clinically studied for its role in GLP-1 signaling, gut barrier integrity, and metabolic regulation. Akkermansia communicates directly with L-cells in the gut lining to support natural GLP-1 production.
Rich in inulin, a prebiotic fiber that specifically feeds Akkermansia muciniphila. Chicory acts as a substrate for Akkermansia to establish and maintain populations in your gut. Works with Beta Glucan as part of the prebiotic fuel system.
Standardized Grape Seed Extract (16% Monomers and 80% oligomeric proanthocyanidins / OPCs). In a 2022 animal study (PMC9834079), grape polyphenols increased Akkermansia in the gut, which is why Vinomerix sits next to live Akkermansia in this formula.
A soluble fiber with dual function: immune support and gut health. Beta Glucan supports healthy blood sugar levels by slowing glucose absorption and, alongside Chicory, helps feed Akkermansia and maintain a healthy gut environment. At 300mg, it provides effective fiber support without the digestive discomfort of higher doses.
FULL LABEL DISCLOSURE
Compare our label against the published research yourself. No proprietary blends, no fairy dust.
| Ingredient | Dose per Serving | Why This Dose |
|---|---|---|
| Sugaheal® | 410 mg | The patented alternative to commodity berberine, dosed at the clinical research level and supporting glucose metabolism through its own distinct pathway. |
| Dihydro Berberine | 20 mg | Up to 5x more bioavailable than standard berberine, at a supporting dose that complements Sugaheal’s separate metabolic pathway without the GI discomfort of high-dose standalone berberine. |
| Akkermansia muciniphila | 20 mg | The keystone gut bacterium. Supports gut lining integrity and talks to the L-cells that release your GLP-1. |
| Chicory Inulin | 200 mg | Prebiotic fiber that acts as a feeding substrate so Akkermansia can establish and maintain healthy populations in the gut. |
| Vinomerix Optima® | 200 mg | Standardized grape seed extract (16% monomers, 80% OPCs) that supports beneficial gut bacteria growth alongside antioxidant defense. |
| Beta Glucan | 300 mg | Soluble fiber that feeds beneficial gut bacteria alongside Chicory and supports a healthy gut environment. |
| Total actives | 1,150 mg | The six doses above, added up. Other ingredients: hypromellose (plant-based capsule), rice flour. |
2 capsules daily · 60 capsules · 30-day supply
The Category Math · Checked October 2026
Prescription GLP-1 shots carry list prices around $1,000 a month. The premium capsules charge more for less: Lemme Reset bills $80 a bottle, Calocurb $89.99, Pendulum GLP-1 Probiotic $89. CLADE carries patented Sugaheal® 410mg, Dihydro Berberine, live Akkermansia and Vinomerix Optima® for $69 one-time, down to $1.50 a day, and every dose is printed on the label.
Official-site prices, checked October 7, 2026: Lemme Reset $80 ($64 per 4 weeks on subscription) · Calocurb GLP-1 Activator $89.99 · Pendulum GLP-1 Probiotic $89 ($64/month on subscription) · Veracity Metabolism Ignite $75
GLP-1 support builds over weeks, so you get the full 90 days to judge it. Not happy? Full refund of that order. No complicated forms, no judgment.
Every subscription delivery ships free within the US, and one-time orders ship free from $69. Orders placed before 2pm EST ship the same day.
Nothing to send back. Email support@cladeprotocol.com with your order number and we refund that order in full, no questions asked.
THE 90-DAY PROTOCOL
Same formula. $1.50 a day. Fewest reorders.
All 3 bottles ship together, free. Billed $135 every 3 months, so you’re never waiting on a reorder.
$45 a bottle ($1.50/day), CLADE’s lowest rate. Plus a free jar of Fiber Protocol ($55 value) with your 3rd delivery.
Manage your plan from your account any time up to 48 hours before your next renewal date.
Every quarterly order carries the full 90-day money-back guarantee, not just your first one.
Independent lab verification for purity, potency, and accurate dosage
Screened for lead, mercury, arsenic, and cadmium below FDA thresholds
Manufactured in a GMP-compliant facility
Every ingredient and its exact dose printed on the label
GLP-1 (glucagon-like peptide-1) is the fullness hormone your gut releases after you eat. It tells your brain you have had enough, and it helps regulate blood sugar, appetite, and metabolic health. It is the signal prescription GLP-1 shots imitate. CLADETM supports your body’s own natural GLP-1 production through three pathways: Sugaheal + Dihydro Berberine for glucose metabolism, Akkermansia for gut-based GLP-1 signaling, and prebiotics (Chicory + Beta Glucan) to maintain the environment where GLP-1-producing cells thrive.
Sugaheal is a patented, standardized botanical extract: not generic berberine powder. It's dosed at 410mg based on clinical research for healthy glucose metabolism, and supports glucose metabolism through a separate metabolic pathway without the GI issues associated with high-dose standalone berberine. CLADETM also includes 20mg of Dihydro Berberine (up to 5x more bioavailable than standard berberine) as a supporting dose to cover a complementary glucose metabolism pathway. Different mechanisms, both at disclosed doses.
Akkermansia muciniphila communicates with L-cells in your gut to support GLP-1 production, but it needs the right environment to colonize. Standardized Vinomerix Optima® (grape seed OPCs) promotes Akkermansia growth (PMC9834079). Chicory acts as a substrate for Akkermansia to establish and maintain populations in your gut, with Beta Glucan providing additional prebiotic support. Together: the bacteria, the fuel, and the growth promoter.
Weeks 1-2 are about the gut side settling in: watch digestion and post-meal cravings. Weeks 3-4 are where to watch afternoon energy and snacking. Weeks 5-12 are where consistency compounds. Everyone is different, which is why the guarantee runs the full 90 days.
CLADETM is a dietary supplement, not a medication and not a replacement for prescription medication. If you take a prescription that affects blood sugar, talk to your doctor before starting so they can monitor your levels.
No, and that is the point. Prescription GLP-1 drugs directly mimic the GLP-1 hormone, with an injection, a prescription and a list price around $1,000 a month. CLADETM is not a drug and not a replacement for prescription GLP-1 medication. It instead supports your body's own natural GLP-1 production through nutritional and microbiome pathways. Talk to your healthcare provider if you're considering or currently on any prescription GLP-1 medication.
Take 2 capsules daily with your largest meal. Taking with food supports absorption and aligns with the natural post-meal metabolic window. Consistency matters more than exact timing.
Side effects are uncommon. Some people notice mild digestive adjustment during the first week as the gut microbiome shifts. Taking with food usually avoids this. If needed, start with one capsule daily for the first week.
Yes. Plant-based hypromellose capsules. Free from gluten, dairy, soy, and GMOs. No artificial additives and no magnesium stearate. Other ingredients: rice flour.
Every plan (90-day, monthly, or one-time) carries a 90-day money-back guarantee. Email support@cladeprotocol.com with your order number and we refund that order in full. You keep the bottles: there is nothing to send back, so no return shipping and no restocking fee.
90-day plan: 3 bottles ship together and you’re billed $135 every 3 months ($45 a bottle). Monthly: 1 bottle for $55 every month. One-time: 1 bottle for $69, no subscription. Subscriptions always ship free, and one-time orders of $69+ ship free. US orders placed before 2pm EST ship the same day and arrive in 3-7 business days.
Yes. A free jar of Fiber Protocol ($55 value) ships with your 3rd subscription delivery, on both the monthly and the 90-day plan. It is a one-time gift per subscription.
Yes, anytime. Open “Manage subscription” in your account to pause, skip, reschedule, or cancel. No calls, no emails. We send a reminder before every renewal, and changes made at least 48 hours before a renewal apply to that renewal.
Complete Your Protocol
GLP-1 Metabolic Support plus Fiber Protocol in one order. Fiber Protocol works the same gut from the other direction: 18 g of fiber and 9 g of protein a scoop.
Just want the fiber? Fiber Protocol from $37/mo.
Patented Sugaheal®. Dihydro Berberine, up to 5x more bioavailable. Live Akkermansia. Every dose on the label, $1.50 a day on the 90-day plan, and 90 days to prove it or your money back.
Then you don’t pay for it. Every plan carries a full 90-day money-back guarantee. Email support@cladeprotocol.com with your order number within 90 days for a full refund of that order. No return required: keep the bottles. Day 30 and day 60 are your checkpoints, so you know where you stand long before the window closes.
You get an email reminder before every renewal. To pause or cancel, open “Manage subscription” in your account. No calls, no forms. Changes made at least 48 hours before a renewal apply to that renewal.
Log into your account portal and select "Skip next order." Your subscription resumes automatically on the following cycle. No charge is processed for the skipped month, and your pricing is preserved when you return.
