Stack fatigue
Your counter looks like a pharmacy shelf
NMN, resveratrol, grape seed, apigenin, magnesium, zinc. Six bottles, six renewal dates, and a stack that falls apart the first week you travel.
One bottle, three capsules, one renewal date.
Built for the biohacker who is done running a six-bottle stack
Four kinds of people end up here. One of them is you.
Beyond NMN alone
You took NMN alone and felt nothing much
You poured NAD+ precursor in for months while CD38 kept burning it off. More in was never the whole answer.
Two NAD+ pathways in, CD38 held back, every dose printed.
Healthy-aging consistency
You feel the 2pm wall and refuse to call it age
Energy that fades by mid-afternoon, recovery that takes a day longer than it used to, focus that quits before you do.
Cellular energy support every morning, in three capsules with breakfast.
Evidence-first
You read the studies, not the influencer captions
You want named pathways, cited research and real milligrams, not a proprietary blend with a longevity font.
Every dose printed, every pathway named. Check the label against the research yourself.
Two Ways In. One Leak Plugged. 510mg of Polyphenols on Top.
Most longevity supplements give you one active and call it a protocol. That is a refill poured into a bucket with a hole in it. CLADETM stacks five layers into one daily dose: more NAD+ in, less NAD+ lost, and the polyphenols most NAD+ bottles leave out.
Layer 1
NAD+ Production
NMN · 255mg
The headline longevity molecule. A direct NAD+ precursor feeding the salvage pathway, at a dose printed on the label.
Layer 2
Second NAD+ Route
Trigonelline 50% · 60mg
A second door to the same molecule: the Preiss-Handler pathway, not the salvage route. Identified as an NAD+ precursor in Nature Metabolism (2024). Almost no NAD+ product has it.
Layer 3
Polyphenol Support
Resveratrol 95 · 300mg
The biggest dose in the formula, standardized to 95%. The polyphenol every longevity conversation starts with, at a dose most blends only put on the front label.
Layer 4
NAD+ Protection
Testosurge® · 150mg
Helps inhibit CD38, the enzyme that eats NAD+ and climbs with age. Making NAD+ without protecting it is paying to fill a leaking tank.
Layer 5
Foundation
Vinomerix Optima® 210mg + Zn, Mg, Folate, B12
Standardized grape OPCs beside the resveratrol, plus cofactors at full daily values and 9mg wheat germ oil to carry the fat-soluble actives.
One NAD+ precursor bottle (Tru Niagen 300mg) is $49 and covers one layer. Polyphenols, CD38 support and cofactors are four or five more bottles.
CLADETM: $69/mo for the full stack
$2.30 a day on the 90-day plan. NAD+ in, NAD+ protected, polyphenols included. One bottle. No CD38 gap.
What 90 days of more NAD+ in, less leaking out is built to do
The best longevity stack is the one you actually take every day. This one is three capsules.
Week 1-2
The 2pm wall starts to move
NMN, Trigonelline and the CD38 support start together on day one. The first thing to watch: your energy at 3pm and how you sleep.
Week 3-4
Focus holds later, recovery speeds up
Polyphenol antioxidant support layers in on top of the NAD+ work. Watch your focus late in the day and how fast you bounce back after training.
Week 6-8
Check your numbers against your baseline
Six to eight weeks of daily NAD+ support with CD38 help. If you track HRV, resting heart rate or sleep, this is a fair window to compare against your own baseline.
Month 3+
This is your new normal
Every layer has had 90 days of daily use. Energy, focus and recovery support as a routine, not a project. This is also where your guarantee window closes, so judge it honestly.
What Changes When Every Pathway Is Active
Before
- An energy wall at 2pm, every single day
- Brain fog you have started blaming on age
- Stiff mornings and a slow bounce-back after training
- 11 pills across 5 or 6 different bottles
- A stack bill north of $100 a month
- "Aging is inevitable, right?"
➔
After
- Cellular energy that carries you into the evening
- Sharp, clear thinking all day
- Faster recovery, better sleep quality
- 3 capsules. One protocol. Done.
- $2.30 a day on the 90-day plan
- "Aging is modifiable."
Why Six Actives Matter
Your Cells Don't Age Through One Mechanism. Why Fight It With One Ingredient?
Standalone NMN targets NAD+ production and stops there. But CD38, an NAD+-consuming enzyme that rises with age, keeps drawing down what you make, and without cofactors the enzymes that use it do not run efficiently. CLADETM is designed as a system: produce NAD+ with NMN, reach it a second way through Trigonelline, protect it from CD38 with apigenin-rich Testosurge, layer polyphenol antioxidant support from Resveratrol and Vinomerix Optima, and supply the minerals and B vitamins that make it all work.
The CD38 Problem Nobody Talks About
NMN Without CD38 Protection Is a Leaking Bucket. We Plugged the Hole.
CD38 is an enzyme that increases with age and consumes NAD+ directly. Research in Cell Metabolism (2016) tied it to the NAD+ decline that comes with age. Most NMN supplements ignore it entirely, so you keep paying to refill what CD38 drains. Testosurge® at 150mg is apigenin-rich, and apigenin is a studied CD38 inhibitor, so more of the NAD+ you make through NMN and Trigonelline stays available. That is the design: make more, lose less.
Polyphenol Support Included
510mg of Resveratrol and Grape OPCs, Built In. Most NAD+ Bottles Give You Zero.
NAD+ is only half the story. Resveratrol 95 at 300mg and Vinomerix Optima at 210mg bring 510mg of polyphenol antioxidant support into the same three capsules, standardized rather than sprinkled. Most NAD+ products are a single precursor in a capsule and leave you to buy antioxidant support separately. Here the polyphenols sit in the same three capsules as the NAD+ actives, not in a second and third bottle you pay for and forget.
One bottle vs. the six-bottle stack
Feature
CLADETM ($79/mo)
Separate bottles
Actives in one bottle
6
1 to 2 (no CD38, no foundation)
Polyphenol support
510 mg (Resveratrol + Vinomerix Optima®)
Sold as a separate bottle
CD38 protection (NAD+ shield)
✓ Testosurge® 150mg
✗ Not included
NAD+ precursor pathways
2 (NMN + Trigonelline)
1 (NMN only)
Essential cofactors (Zn, Mg, Folate, B12)
✓ 100% DV
✗ Buy separately
Daily capsules
3
Several, across separate bottles
Every dose on the label
✓
Varies by brand
Monthly cost
$79 (or $69 quarterly)
$49 for one precursor; $106+ for the full stack
Third-party tested
✓
Varies
THE MATH
Build This Stack Yourself and Pay $106 to $149 a Month
Five or six separate bottles to cover the same five layers. Here is the bill, next to ours.
What You’d Buy Separately
Monthly Cost
NAD+ precursor
Tru Niagen 300mg, 30 servings (one precursor, NR)
$49
CD38 support
a standalone apigenin bottle
$15–25
Polyphenols
a resveratrol bottle plus a grape seed OPC bottle
$32–55
Mineral and B-vitamin base
a separate zinc, magnesium and B-vitamin product
$10–20
The do-it-yourself stack
$106–149 /mo
CLADE Longevity Complex (90-day quarterly)
$69 /mo
You keep$37–80a month, plus a second NAD+ route most stacks never get
Tru Niagen 300mg (30 count) is $49 one-time on truniagen.com, checked October 2026. The other rows are our estimate of typical single-ingredient bottle prices; your brands may cost more or less. Trigonelline, the second NAD+ route, is not counted at all because it is hard to find on its own.
Different longevity goals. One simpler protocol.
D
David K.
Age 54
★★★★★
"Consolidated from 5 supplements to 1"
I was the guy with the weekly pill organizer and a big monthly supplement budget. Standalone NMN, a resveratrol bottle, apigenin, plus magnesium and zinc. When I lined those up against the CLADETM label, it was a no-brainer. Two months in and my Oura ring data backs it up: HRV is up, resting heart rate is down.
S
Dr. Sarah L.
PhD biochemistry
★★★★★
"The formulation logic is sound"
Most longevity stacks are marketing-driven assemblages. CLADETM actually addresses the CD38 degradation problem that makes standalone NMN supplements wasteful. The inclusion of Trigonelline for the Preiss-Handler NAD+ pathway after the Nature publication shows someone is reading the literature, not just the competitor labels.
M
Michael R.
Age 47
★★★★★
"Pill fatigue was killing my consistency"
I know the science. I've been following Attia and Huberman for years. But taking 11 capsules every morning across four bottles was unsustainable. I'd skip days, forget bottles when traveling. Three capsules a day, every day, no exceptions. Consistency is the actual longevity intervention here.
R
Rachel W.
Age 58
★★★★★
"My afternoon brain fog vanished"
At 58, I accepted that the 2pm mental fade was just part of aging. Four weeks into CLADETM, I realized I'd been working straight through to 5pm without noticing. My husband started taking it after seeing the change in me. Neither of us are willing to stop now.
A
Alex T.
Age 39
★★★★☆
"The CD38 blocking is the real story"
Everyone talks about NMN dosing, but the Testosurge CD38 blocker is the underrated piece here. I was taking 500mg NMN alone and not seeing the results I expected. CLADETM gives you 255mg NMN with CD38 protection, plus five other actives. I'm a biohacker who tracks everything, and my recovery metrics improved more in three weeks than months of standalone NMN.
J
James H.
Age 52
★★★★★
"Four bottles, and still missing CD38 protection"
I did the math on my old stack: a standalone NMN, a resveratrol, a grape seed extract, plus zinc and magnesium. Four bottles and I was still missing CD38 protection entirely. CLADETM covers all of it for $79 on the monthly plan. The synergy design justified the switch, but the results confirmed it.
Dosed to Work, Not to Decorate the Label
Every dose is set against the published research for that ingredient, then printed on the label so you can check it. No fairy-dusted sprinkle doses hiding in a proprietary blend. No mega-dose of one ingredient to cover for missing the rest. You can finally stop second-guessing.
Resveratrol 95 (Polyphenol Support)
300 mg
UnderdosedOptimal ZoneOverdosed
Vinomerix Optima® (Grape OPCs)
210 mg
UnderdosedOptimal ZoneOverdosed
NMN + Testosurge® CD38 Support (NAD+ System)
255 mg + 150 mg
UnderdosedOptimal ZoneOverdosed
Trigonelline 50% (NAD+ Alt Pathway)
60 mg
UnderdosedOptimal ZoneOverdosed
Zinc + Magnesium + Methyl Folate + B12 (Foundation)
100% DV
UnderdosedOptimal ZoneOverdosed
Every Active, Every Dose, Every Reason
Six actives chosen to push NAD+ up, keep it from draining, and cover the polyphenols single-ingredient bottles skip. Every dose printed on the label.
CD38 Support
Testosurge® (Apigenin-rich)
150 mg
A standardized, apigenin-rich extract chosen for one job: helping inhibit CD38, the enzyme that consumes NAD+ and rises with age. Without CD38 support, more of the NAD+ you make from NMN is used up before it does its work. Pairing the two is the systems approach standalone NMN products skip.
Dual NAD+ Pathway
NMN
255 mg
Nicotinamide mononucleotide, a direct NAD+ precursor. Part of CLADETM's dual-pathway NAD+ production system. At 255mg paired with Testosurge CD38 support, the goal is NAD+ that is made and then kept, not made and lost. Making more while protecting what you have: the systems approach to NAD+ that standalone NMN supplements miss.
Resveratrol 95
300 mg
The most studied polyphenol in the longevity category, standardized to 95 percent rather than sold as a crude extract. At 300mg it is the largest active in the formula, and it carries the antioxidant side of the protocol alongside Vinomerix Optima. Most NAD+ products leave polyphenol support out entirely and expect you to buy it in a second bottle.
Vinomerix Optima®
210 mg
A standardized grape polyphenol extract rich in OPCs, included at 210mg per serving. It sits beside the resveratrol so the antioxidant side of the protocol comes from two standardized sources rather than one. Formulas that name a polyphenol without printing its dose are asking you to take the amount on trust.
Trigonelline 50%
60 mg
Trigonelline reaches NAD+ through a separate route, the Preiss-Handler pathway, so the formula does not rely on the NMN salvage route alone. A 2024 study in Nature Metabolism identified trigonelline as an NAD+ precursor that raised NAD+ levels in preclinical models and human muscle cells.
Zinc + Magnesium + Methyl Folate + B12
100% DV
Zinc bisglycinate (11mg), magnesium glycinate (420mg), methyl folate, and vitamin B12 at 100% of the Daily Value, plus 9mg of wheat germ oil to carry the fat-soluble actives. These aren't filler. Zinc is a cofactor for 300+ enzymes including those in NAD+ metabolism. Magnesium is required for mitochondrial ATP production. Full daily values, not token sprinkle doses.
FULL LABEL DISCLOSURE
Every milligram. Printed. Checkable.
Hold our label next to any longevity bottle you own. No proprietary blends, no fairy dust, nothing to hide.
| Ingredient | Dose per Serving | Why This Dose |
|---|---|---|
| Resveratrol 95 | 300 mg | Standardized polyphenol that provides antioxidant support for everyday cellular health. |
| NMN | 255 mg | A NAD+ precursor that enters the body’s salvage pathway for cellular energy production. |
| Vinomerix Optima® | 210 mg | Standardized grape polyphenol extract rich in OPCs, included alongside the resveratrol. |
| Testosurge® | 150 mg | Apigenin-rich extract included to help inhibit CD38, the enzyme that consumes NAD+. |
| Trigonelline 50% | 60 mg | Standardized extract that supports NAD+ production through the separate Preiss-Handler pathway. |
| Wheat Germ Oil | 9 mg | Lipid carrier that supports absorption of the fat-soluble actives. |
| Zinc & Magnesium | 11 mg + 420 mg (100% DV) | Foundational minerals that support everyday cellular function. |
| Methyl Folate & Vitamin B12 | 100% DV | Methylated B vitamins for everyday nutritional support. |
| Other ingredients | N/A | Plant-based capsule (hypromellose), rice flour. |
3 capsules daily · 90 capsules · 30-day supply
The Category Math · Checked October 2026
One NAD+ Precursor Runs $49 to $65. The Full Stack Runs $69.
Single-pathway NAD+ bottles do one job and stop. Longevity Complex runs five layers: NMN, Trigonelline, CD38 support, 510mg of polyphenols and a full-DV cofactor base. Printed doses, one bottle.
$49Tru Niagen 300mg: one precursor (NR), 30 servings
$65Elysium Basis: NR plus pterostilbene, 30-day pouch
$69/moCLADE on the 90-day protocol: $2.30 a day for five layers
Official-site one-time prices, checked October 2026: truniagen.com $49 · elysiumhealth.com $65
You Risk Nothing. We Carry the Refund.
90 Days to Feel It, or Every Dollar Back
Cellular changes take time. If you don't notice improvements in energy, clarity, or recovery within 90 days, on any plan, we refund that order in full. No forms, no hassle.
Free US Shipping
Every subscription delivery ships free within the US, and so does the $99 one-time bottle. No minimum order, no coupon codes.
No Return Needed
If it doesn't work for you, email support@cladeprotocol.com with your order number. You keep the bottles: nothing to box up, no return label, no restocking fee.
THE 90-DAY PLAN
The 90-Day Plan: Lowest Price, Free Fiber Jar, Zero Lock-In
The lowest price per bottle, one delivery per quarter, and a free Fiber Protocol jar on your 3rd delivery.
One Quarterly Delivery
Your full 90-day supply ships in a single shipment, so you’re never waiting on a reorder.
Best Per-Month Price
The 90-day plan is priced at $69/mo, CLADE’s lowest rate across every tier.
Pause, Skip, or Cancel Anytime
Manage your plan from your account any time up to 48 hours before your next renewal date. No phone call, no fee.
Free Fiber Protocol Jar
Your 3rd subscription delivery includes a free jar of Fiber Protocol, a $55 value.
Proof, Not Promises
Third-Party Tested
Independent lab verification for purity, potency, and accurate dosage
Heavy Metal Tested
Every batch screened for lead, mercury, arsenic, and cadmium
GMP Certified
Manufactured in a GMP-compliant facility
No Proprietary Blends
Every ingredient and every dose disclosed on the label
Questions Worth Asking Before You Buy
Six actives, 984mg total per three-capsule serving, working across two mechanisms. NAD+ support comes from NMN at 255mg, which enters the salvage pathway, Trigonelline 50% at 60mg, which reaches NAD+ through the Preiss-Handler pathway, and apigenin-rich Testosurge at 150mg, which helps inhibit CD38, the enzyme that consumes NAD+ and rises with age. Polyphenol antioxidant support comes from Resveratrol 95 at 300mg and Vinomerix Optima at 210mg. Wheat germ oil at 9mg carries the fat-soluble actives, and zinc, magnesium, methyl folate and vitamin B12 sit at 100% DV as the cofactor base.
Because making NAD+ is only half of it, and it is the half everyone sells. CD38 is an enzyme that rises with age and consumes NAD+ directly; research ties it to the age-related NAD+ decline. Taking NMN without addressing CD38 is filling a leaking bucket and paying for the water twice. Testosurge in CLADETM is there to help inhibit CD38, so more of the NAD+ made from NMN and Trigonelline stays available.
A single-precursor bottle such as Tru Niagen 300mg ($49 on truniagen.com, checked October 2026) works one route to NAD+. Longevity Complex gives you two routes (NMN and Trigonelline), CD38 support from Testosurge, 510mg of polyphenols and a full-DV cofactor base. If one precursor is all you want, that bottle costs less. If you want the whole system in one bottle, that is what we built: $69 a month on the 90-day plan.
Yes. In 2022 the FDA took the position that NMN could not be sold as a dietary supplement. On September 29, 2025 it reversed that position and confirmed NMN is lawful in dietary supplements, after reviewing evidence that NMN was sold as a supplement in the US as early as 2017. Our NMN is printed on the label: 255mg per serving.
Because they are different polyphenols and they are both standardized. Resveratrol 95 at 300mg is the single largest active in the formula. Vinomerix Optima at 210mg adds grape-derived OPCs on top of it, bringing the polyphenol total to 510mg per serving. Running two standardized sources rather than one larger dose of a single extract is the same logic we apply to NAD+, where NMN and Trigonelline reach the same molecule by different routes. Most NAD+ products include no polyphenol support at all.
Because the formula is built as a system, not a single number. Most standalone NMN products lean on a big dose because NMN is all they have. Here, NMN at 255mg works alongside Testosurge for CD38 support and Trigonelline as a second, independent route to NAD+ through the Preiss-Handler pathway. Three inputs pulling in the same direction, each dose printed on the label.
Trigonelline is a naturally occurring alkaloid found in coffee. A 2024 study in Nature Metabolism (Membrez et al.) identified it as an NAD+ precursor: it entered the NAD+ pool and raised NAD+ levels in worms, mice and human muscle cells. It reaches NAD+ through the Preiss-Handler pathway, a different route from NMN and NR, which gives the formula a second, independent way to the same molecule.
Give it the full 90 days. NAD+ support starts on day one and the polyphenol support builds over the following weeks. Watch your afternoon energy and sleep first, then recovery and focus. If you track HRV or resting heart rate, compare week 8 with your own baseline. The 90-day guarantee covers the whole window, on every plan.
Yes. CLADETM is designed to replace standalone NMN, resveratrol, grape seed extract, and basic mineral supplements. If you're currently taking any of these individually, you can transition to CLADETM as a consolidated protocol. For any prescription medications, consult your healthcare provider before starting.
Plant-based capsules. Free from gluten, dairy, soy, and GMOs. No artificial additives or magnesium stearate; the only non-active ingredients are the hypromellose capsule and rice flour. Note: contains wheat germ oil. If you have a wheat allergy, consult your healthcare provider.
90-day money-back guarantee on every plan: 90-day, monthly, or one-time. If you're not satisfied for any reason, email support@cladeprotocol.com with your order number within 90 days for a full refund of that order. No return needed: keep the bottles. No forms, no restocking fee.
Complete Your Protocol
The Vitality Protocol
Cellular energy plus drive, strength and stamina, in one order. The NAD+ and polyphenol layers here, next to Testosurge® 500mg, KSM-66® Ashwagandha 200mg and standardized Shilajit extract (60% fulvic acid). 650mg of Testosurge® a day across both.
Monthly$109vs $124 bought separately
90-day$99/movs $106 bought separately
One-time$129vs $154 bought separately
Stop Refilling a Leaking Bucket.
NAD+ in through two pathways. CD38 held back. 510mg of polyphenols on top. One bottle replaces five or six, for $2.30 a day on the 90-day plan, with free shipping and 90 full days to judge it. If it does not deliver, you get your money back and keep the bottles.
Before you commit
What if I don't see results?
Every plan is covered by a 90-day money-back guarantee. If you reach Day 90 without noticing a difference in your daily energy, recovery, or focus, email support@cladeprotocol.com with your order number for a full refund. Keep the bottles. No questions, no hoops. The Day 30 and Day 60 timeline milestones give you real checkpoints to assess each pathway before the 90 days run out.
What if I forget to cancel?
You get an email reminder before every renewal charge. To pause, skip or cancel, open Manage subscription in your CLADE account (the link is also in the footer) up to 48 hours before your renewal date. No phone call, no cancellation fee.
What if I need to skip a month?
Open Manage subscription in your account and skip the upcoming delivery. Your subscription resumes automatically on the following cycle and you are not charged for the skipped period. You can skip as many cycles as you need without cancelling your subscription or losing your pricing.
Longevity Complex
Full NAD+ Stack · 3 Caps/Day
The 90-Day Cellular Reset Protocol
$69/mo
Save 30%
Monthly Longevity Routine
$79/mo
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Starter Bottle
$99 one-time
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