Stack fatigue
You are tired of managing five separate longevity products
Too many bottles, too many renewals, and too much mental overhead to stay consistent.
CLADE is positioned as a simpler daily protocol instead of another stack expansion.
Built for people who want longevity support without the stack chaos
Four kinds of people end up here. See which one you are.
Beyond NMN alone
You know one active is not enough
You have already learned that an NMN capsule on its own does not equal full longevity coverage.
Six actives with printed doses are easier to verify and easier to commit to.
Healthy-aging consistency
You want something you can realistically stay on
You care about long-term support but do not want a fragile routine held together by perfect discipline.
CLADE compresses the story into one clearer protocol with fewer ways to fall off.
Evidence-first
You want more than aspirational longevity branding
You read the science and want claims that feel more structured than category hype.
Transparent dosing and pathway framing give you a formula you can actually verify.
The NAD+ and Polyphenol Cellular Protocol
Most longevity supplements give you one active and call it a protocol. CLADETM puts six of them in a single daily dose, built around NAD+ support and polyphenol antioxidant support.
Layer 1
NAD+ Production
NMN · 255mg
A direct NAD+ precursor feeding the salvage pathway, at a dose you can read off the label.
Layer 2
Second NAD+ Route
Trigonelline 50% · 60mg
Reaches NAD+ through the Preiss-Handler pathway instead of the salvage route. Published in Nature Medicine.
Layer 3
Polyphenol Support
Resveratrol 95 · 300mg
The largest active in the formula. Antioxidant support at a dose most blends reserve for the label, not the capsule.
Layer 4
NAD+ Protection
Testosurge® · 150mg
Blocks CD38, the enzyme that destroys 90% of your NAD+ as you age. Producing NAD+ without protecting it is waste.
Layer 5
Foundation
Vinomerix Optima® 210mg + Zn, Mg, Folate, B12
Standardized grape OPCs beside the resveratrol, plus cofactors at full daily values and 9mg wheat germ oil to carry the fat-soluble actives.
NMN $45 + resveratrol $30 + grape seed OPCs $15 + minerals $32 = $122/mo, still with no CD38 protection
CLADETM: $79/mo for all six actives
NAD+ production, NAD+ protection, and polyphenol support. One protocol. No CD38 gap.
What most people notice when they stay consistent
Longevity protocols work best when they are simple enough to stay on and broad enough to matter.
Week 1-2
Energy stabilizes, sleep deepens
NAD+ precursors begin restoring cellular fuel. Most users report steadier energy without the afternoon crash. Sleep quality improves as mitochondrial function begins to normalize.
Week 3-4
Mental clarity sharpens, recovery accelerates
Polyphenol antioxidant support layers in on top of the NAD+ work. Cognitive function feels noticeably sharper. Post-exercise recovery time decreases. Morning stiffness reduces.
Week 6-8
Compounding effects become measurable
NAD+ support has had time to accumulate rather than being burned off by CD38. HRV improvements become trackable. Sustained all-day energy is the new baseline, not the exception.
Month 3+
Deep cellular renewal established
All six actives operating at full capacity. Consistent energy, cognitive clarity, and physical resilience. Biomarker improvements visible in bloodwork. This is what cellular maintenance feels like.
What Changes When Every Pathway Is Active
Before
- Afternoon energy crashes by 2pm
- Brain fog you blame on age
- Waking up stiff with slow recovery
- 11 pills across 4 different bottles
- $122/mo on separate supplements
- "Aging is inevitable, right?"
➔
After
- Sustained energy from morning to evening
- Sharp, clear thinking all day
- Faster recovery, better sleep quality
- 3 capsules. One protocol. Done.
- $79/mo for the complete protocol
- "Aging is modifiable."
Why Six Actives Matter
Your Cells Don't Age Through One Mechanism. Why Target It With One?
Standalone NMN targets NAD+ production and stops there. But CD38 destroys 90% of the NAD+ you produce, and without cofactors the enzymes that use it do not run efficiently. CLADETM is designed as a system: produce NAD+ with NMN, reach it a second way through Trigonelline, protect it from CD38 with apigenin-rich Testosurge, layer polyphenol antioxidant support from Resveratrol and Vinomerix Optima, and supply the minerals and B vitamins that make it all work.
The CD38 Problem Nobody Talks About
Taking NMN Without CD38 Protection Is Like Filling a Leaking Bucket
CD38 is an enzyme that increases with age and inflammation. It consumes NAD+ directly, destroying up to 90% of your cellular fuel reserves. Most NMN supplements ignore this entirely. Testosurge (standardized apigenin-rich fenugreek) at 150mg blocks CD38 activity, meaning more of the NAD+ you produce through NMN and Trigonelline actually reaches your cells. With 255mg NMN plus CD38 protection, your net NAD+ accumulation can exceed what a larger unprotected dose achieves when CD38 goes unchecked.
Polyphenol Support Included
510mg of Polyphenols Built In. Most NAD+ Products Skip Them Entirely.
NAD+ is only half the story. Resveratrol 95 at 300mg and Vinomerix Optima at 210mg bring 510mg of polyphenol antioxidant support into the same three capsules, standardized rather than sprinkled. Most NAD+ products are a single precursor in a capsule and leave you to buy antioxidant support separately. The real value here is that the polyphenols sit alongside the NAD+ actives instead of in another bottle you have to remember.
Why CLADE feels stronger than buying longevity ingredients one by one
Feature
CLADETM ($79/mo)
Separate Products ($122)
Actives in one bottle
6
1 to 2 (no CD38, no foundation)
Polyphenol support
510 mg (Resveratrol + Vinomerix Optima®)
Sold as a separate bottle
CD38 protection (NAD+ shield)
✓ Testosurge 150mg
✗ Not included
NAD+ precursor pathways
2 (NMN + Trigonelline)
1 (NMN only)
Essential cofactors (Zn, Mg, Folate, B12)
✓ Full RDI
✗ Buy separately
Daily capsules
3
8-11 across brands
Every dose on the label
✓
Varies by brand
Monthly cost
$79 (or $65 quarterly)
$122 at mid-market prices
Third-party tested
✓
Varies
THE MATH
What Replacing This Stack Costs Separately
The actives above are already covered in one formula. Here is what the same coverage costs assembled bottle by bottle.
What You’d Buy Separately
Monthly Cost
NAD+ precursor support
via a standalone NMN supplement
$45
CD38 protection
via a standalone apigenin supplement
Rarely sold
Polyphenol antioxidant support
via a standalone resveratrol bottle plus a grape seed OPC bottle
$45
Mineral and B-vitamin base
via a separate zinc, magnesium and B-vitamin product
$32
Total stacked separately
$122 /mo
CLADE Longevity Complex (90-day quarterly)
$65 /mo
You save$57per month on the 90-day plan
Mid-market pricing for single-ingredient products covering the same six actives. Premium brands run well past this. Apigenin is rarely sold as a standalone consumer product, so it is not counted in the total. Verify current pricing directly with each brand.
Different longevity goals. One simpler protocol.
D
David K.
Age 54
★★★★★
"Consolidated from 5 supplements to 1"
I was the guy with the weekly pill organizer and a big monthly supplement budget. Standalone NMN, a resveratrol bottle, apigenin, plus magnesium and zinc. When I lined those up against the CLADETM label, it was a no-brainer. Two months in and my Oura ring data backs it up: HRV is up, resting heart rate is down.
S
Dr. Sarah L.
PhD biochemistry
★★★★★
"The formulation logic is sound"
Most longevity stacks are marketing-driven assemblages. CLADETM actually addresses the CD38 degradation problem that makes standalone NMN supplements wasteful. The inclusion of Trigonelline for the Preiss-Handler NAD+ pathway after the Nature publication shows someone is reading the literature, not just the competitor labels.
M
Michael R.
Age 47
★★★★★
"Pill fatigue was killing my consistency"
I know the science. I've been following Attia and Huberman for years. But taking 11 capsules every morning across four bottles was unsustainable. I'd skip days, forget bottles when traveling. Three capsules a day, every day, no exceptions. Consistency is the actual longevity intervention here.
R
Rachel W.
Age 58
★★★★★
"My afternoon brain fog vanished"
At 58, I accepted that the 2pm mental fade was just part of aging. Four weeks into CLADETM, I realized I'd been working straight through to 5pm without noticing. My husband started taking it after seeing the change in me. Neither of us are willing to stop now.
A
Alex T.
Age 39
★★★★☆
"The CD38 blocking is the real story"
Everyone talks about NMN dosing, but the Testosurge CD38 blocker is the underrated piece here. I was taking 500mg NMN alone and not seeing the results I expected. CLADETM gives you 255mg NMN with CD38 protection, plus five other actives. I'm a biohacker who tracks everything, and my recovery metrics improved more in three weeks than months of standalone NMN.
J
James H.
Age 52
★★★★★
"Four bottles, and still missing CD38 protection"
I did the math on my old stack: a standalone NMN, a resveratrol, a grape seed extract, plus zinc and magnesium. Four bottles and I was still missing CD38 protection entirely. CLADETM covers all of it for $79 on the monthly plan. The synergy design justified the switch, but the results confirmed it.
Dosed in the Optimal Zone
After studying hundreds of clinical research reports, we dosed every ingredient at the exact level where published data showed peak efficacy. Not underdosed to cut costs. Not overdosed to impress on a label. The precise dose where biology responds best. You can finally stop second-guessing.
Resveratrol 95 (Polyphenol Support)
300 mg
UnderdosedOptimal ZoneOverdosed
Vinomerix Optima® (Grape OPCs)
210 mg
UnderdosedOptimal ZoneOverdosed
NMN + Testosurge® CD38 Blocking (NAD+ System)
255 mg + 150 mg
UnderdosedOptimal ZoneOverdosed
Trigonelline 50% (NAD+ Alt Pathway)
60 mg
UnderdosedOptimal ZoneOverdosed
Zinc + Magnesium + Methyl Folate + B12 (Foundation)
100% RDI
UnderdosedOptimal ZoneOverdosed
The Science Behind Every Capsule
Six actives selected for NAD+ coverage, dose justification, and synergistic interaction. Every dose printed on the label.
CD38 Blocker
Testosurge® (Apigenin-rich)
150 mg
A standardized, apigenin-rich fenugreek extract that inhibits CD38, the enzyme responsible for degrading up to 90% of NAD+ as you age. Without CD38 protection, most of the NAD+ your body produces through NMN supplementation is destroyed before it reaches your cells. This is why CLADETM's NMN with CD38 blocking delivers better net NAD+ accumulation than standalone mega-dose NMN products that leave CD38 unchecked.
Dual NAD+ Pathway
NMN
255 mg
Nicotinamide mononucleotide, a direct NAD+ precursor. Part of CLADETM's dual-pathway NAD+ production system. At 255mg paired with Testosurge CD38 blocking, the NAD+ you produce actually accumulates rather than being immediately destroyed. Producing more while protecting what you have is more efficient than mega-dosing production alone. This is the systems-design approach to NAD+ that standalone NMN supplements miss.
Resveratrol 95
300 mg
The most studied polyphenol in the longevity category, standardized to 95 percent rather than sold as a crude extract. At 300mg it is the largest active in the formula, and it carries the antioxidant side of the protocol alongside Vinomerix Optima. Most NAD+ products leave polyphenol support out entirely and expect you to buy it in a second bottle.
Vinomerix Optima®
210 mg
A standardized grape polyphenol extract rich in OPCs, included at 210mg per serving. It sits beside the resveratrol so the antioxidant side of the protocol comes from two standardized sources rather than one. Formulas that name a polyphenol without printing its dose are asking you to take the amount on trust.
Trigonelline 50%
60 mg
Trigonelline is converted to NAD+ through a distinct mechanism: the Preiss-Handler pathway: that is more efficient than the NMN salvage pathway. Trigonelline 50% enters the Preiss-Handler pathway and promotes NAD+ production via multiple enzymatic steps. Research published in Nature Medicine supports this role as a NAD+ precursor.
Zinc + Magnesium + Methyl Folate + B12
100% RDI
Zinc bisglycinate (11mg), magnesium glycinate (420mg), methyl folate, and vitamin B12 at full recommended daily values, plus 9mg of wheat germ oil to carry the fat-soluble actives. These aren't filler. Zinc is a cofactor for 300+ enzymes including those in NAD+ metabolism. Magnesium is required for mitochondrial ATP production. Full daily values, not token sprinkle doses.
FULL LABEL DISCLOSURE
Every milligram. Printed. Checkable.
Compare our label against the published research yourself. No proprietary blends, no fairy dust.
| Ingredient | Dose per Serving | Why This Dose |
|---|---|---|
| Resveratrol 95 | 300 mg | Standardized polyphenol that provides antioxidant support for everyday cellular health. |
| NMN | 255 mg | A NAD+ precursor that enters the body’s salvage pathway for cellular energy production. |
| Vinomerix Optima® | 210 mg | Standardized grape polyphenol extract rich in OPCs, included alongside the resveratrol. |
| Testosurge® | 150 mg | Standardized, clinically studied extract that supports NAD+ and ATP levels alongside healthy physical performance. |
| Trigonelline 50% | 60 mg | Standardized extract that supports NAD+ production through a separate, non-flushing pathway. |
| Wheat Germ Oil | 9 mg | Lipid carrier that supports absorption of the fat-soluble actives. |
| Zinc & Magnesium | As per RDI | Foundational minerals that support everyday cellular function. |
| Methyl Folate & Vitamin B12 | As per RDI | Methylated B vitamins for everyday nutritional support. |
| Excipients (capsule, anti-caking) | — | Standard capsule fill. |
3 capsules daily · 90 capsules · 30-day supply
Your Purchase Is Protected
90-Day Risk-Free Trial
Cellular changes take time. If you don't notice improvements in energy, clarity, or recovery within 90 days on the quarterly plan, we'll refund you in full. No forms, no hassle.
Free Shipping on Subscriptions
Every subscription delivery ships free within the US. No minimum order, no coupon codes. The protocol arrives on schedule, every time.
Instant Refunds
If it doesn't work for you, we process your refund immediately. No waiting period, no restocking fee. We want you to feel the difference, not feel trapped.
THE PROTOCOL 90 MEMBERSHIP
Quarterly Members Get More Than a Discount
The 90-day plan is a full CLADE membership tier, not just a lower price.
One Quarterly Delivery
Your full 90-day supply ships in a single shipment, so you’re never waiting on a reorder.
Best Per-Month Price
The 90-day plan is priced at $65/mo, CLADE’s lowest rate across every tier.
Pause, Skip, or Cancel Anytime
Manage your plan from your account any time up to 48 hours before your next renewal date.
Full 90-Day Guarantee
Every quarterly order carries the full 90-day money-back guarantee, not just your first one.
Proof, Not Promises
Third-Party Tested
Independent lab verification for purity, potency, and accurate dosage
Heavy Metal Tested
Screened for lead, mercury, arsenic, and cadmium below FDA thresholds
GMP Certified
Manufactured in a GMP-compliant facility
No Proprietary Blends
Every ingredient and every dose disclosed on the label
Questions Worth Asking Before You Buy
Six actives, 984mg total per three-capsule serving, working across two mechanisms. NAD+ support comes from NMN at 255mg, which enters the salvage pathway, Trigonelline 50% at 60mg, which reaches NAD+ through the Preiss-Handler pathway, and apigenin-rich Testosurge at 150mg, which blocks the CD38 enzyme that degrades up to 90% of NAD+ as you age. Polyphenol antioxidant support comes from Resveratrol 95 at 300mg and Vinomerix Optima at 210mg. Wheat germ oil at 9mg carries the fat-soluble actives, and zinc, magnesium, methyl folate and vitamin B12 sit at 100% RDI as the cofactor base.
Because CD38 destroys most of the NAD+ you produce. CD38 is an enzyme that increases with age and inflammation, consuming up to 90% of your NAD+ reserves. Taking NMN without addressing CD38 is like filling a leaking bucket. Testosurge in CLADETM blocks CD38 activity, meaning significantly more of the NAD+ produced through NMN actually reaches your cells. With 255mg NMN plus CD38 protection, your net NAD+ accumulation can exceed what a larger unprotected dose achieves.
They are different products solving different problems. Timeline (Mitopure) focuses exclusively on mitophagy via Urolithin A at 500mg for $125/month. CLADETM does not contain Urolithin A and does not compete on that mechanism. Our formula is built around NAD+ support, with NMN, Trigonelline and CD38 protection from apigenin-rich Testosurge, plus 510mg of polyphenol antioxidant support from Resveratrol and Vinomerix Optima. If mitophagy specifically is what you are after, Timeline is the product for that. If you want NAD+ and polyphenol coverage in one bottle at $79/month, that is what we built.
Because they are different polyphenols and they are both standardized. Resveratrol 95 at 300mg is the single largest active in the formula. Vinomerix Optima at 210mg adds grape-derived OPCs on top of it, bringing the polyphenol total to 510mg per serving. Running two standardized sources rather than one larger dose of a single extract is the same logic we apply to NAD+, where NMN and Trigonelline reach the same molecule by different routes. Most NAD+ products include no polyphenol support at all.
Because with CD38 blocking, the system-level approach matters more than raw dosage. Most standalone NMN supplements lean on a large number because they don't address the CD38 degradation pathway at all. Without CD38 inhibition, much of the supplemented NAD+ is consumed before reaching target cells. With Testosurge blocking CD38, 255mg NMN produces NAD+ that actually accumulates rather than being immediately destroyed. Trigonelline then provides a second, independent NAD+ production route via the Preiss-Handler pathway. The net NAD+ gain from 255mg NMN plus CD38 protection can exceed what you get from a larger unprotected dose.
Trigonelline is a naturally occurring alkaloid found in coffee and fenugreek. Research published in Nature Medicine (2023) identified it as a novel NAD+ precursor that operates through a biochemical pathway distinct from NMN and NR. This means it provides a redundant route to NAD+ production. Including it alongside NMN creates two independent production pathways, reducing dependence on any single mechanism.
Most users report energy and sleep improvements within 1-2 weeks as NAD+ levels begin to restore. Cognitive clarity and recovery improvements typically appear at weeks 3-4 as the polyphenol support layers in. Measurable biomarker changes (HRV, resting heart rate) often show at 6-8 weeks. The quarterly plan is recommended because cellular renewal compounds over time. Our 90-day guarantee covers this full window.
Yes. CLADETM is designed to replace standalone NMN, resveratrol, grape seed extract, and basic mineral supplements. If you're currently taking any of these individually, you can transition to CLADETM as a consolidated protocol. For any prescription medications, consult your healthcare provider before starting.
Plant-based capsules. Free from gluten, dairy, soy, and GMOs. No artificial additives, fillers, or magnesium stearate. Note: contains wheat germ oil. If you have a wheat allergy, consult your healthcare provider.
90-day satisfaction guarantee on the quarterly plan. 30-day guarantee on the monthly plan. If you're not satisfied for any reason, contact us within the guarantee period for a full refund. No complicated forms, no restocking fees. We cover return shipping.
Complete Your Protocol
GLP-1 Metabolic Support
Healthy aging and metabolic health share the same pathways. Most members run both formulas together.
from $39/mo
View Formula →Ready to replace the longevity stack with one clearer daily protocol?
Six actives. Transparent doses. Fewer bottles. Start with the quarterly plan for the cleanest value story and the full 90-day risk-free trial.
Before you commit
What if I don't see results?
Every quarterly plan is covered by a 90-day money-back guarantee. If you reach Day 90 without noticing a difference in your daily energy, recovery rate, or biological-age trajectory, contact support for a full refund. No questions, no hoops. The Day 30 and Day 60 timeline milestones give you real checkpoints to assess each pathway before the 90 days run out.
What if I forget to cancel?
You will receive an email reminder before every renewal charge. To pause or cancel, log in to your CLADE account, go to Subscriptions, and click Pause or Cancel. One click, no phone call, takes effect immediately. There is no cancellation fee.
What if I need to skip a month?
Log in to your account and skip the upcoming delivery from the Subscriptions page. Your subscription resumes automatically on the following cycle and you are not charged for the skipped period. You can skip as many cycles as you need without cancelling your subscription or losing your pricing.
Longevity Complex + Cellular Protocol
90 Capsules · Six Actives
The 90-Day Cellular Reset Protocol
$65/mo
Save 34%
Monthly Longevity Routine
$79/mo
Save 20%
Starter Bottle
$99 one-time
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