Stop Managing Multiple Longevity Supplements.
Start the NAD+ and Polyphenol Protocol.
Your NMN, resveratrol, apigenin, and minerals replaced by one 3-capsule daily protocol at $79/mo. Ingredient-by-ingredient comparison below.
See the Full Ingredient Comparison
If you are reading this, your medicine cabinet probably tells the story. NMN from one brand. Resveratrol from another. An apigenin bottle you have to hunt for. Magnesium, zinc, folate scattered across the shelf.
You are spending real money across separate subscriptions for overlapping coverage. You are swallowing capsules from a handful of different bottles before breakfast. You are managing reorder dates from 4 different companies. And somewhere in the back of your mind, a question you have been avoiding:
Is my NMN actually reaching my cells?
Because here is the part most longevity supplement companies do not talk about. An enzyme called CD38 increases with age and destroys up to 90% of your cellular NAD+ before it can do anything useful. Taking NMN without blocking CD38 is like filling a bucket with a hole in the bottom.
This guide breaks down the two cellular aging mechanisms that matter most for long-term cell health, shows you what each of your current supplements covers (and what they miss), and introduces a single protocol that addresses both for $79/mo.
Your Cells Age Across Two Mechanisms. Most Supplements Address One.
Your body ages at the cellular level through several mechanisms, but two matter most for a coordinated longevity protocol: NAD+ decline and oxidative stress. Each degrades independently. Targeting just one (like most single-ingredient supplements do) leaves the other unaddressed.
Polyphenol Defense: Resveratrol 95
Resveratrol is a well-studied polyphenol linked to antioxidant support at the cellular level. CLADE uses Resveratrol 95 at a 300mg dose, the same ingredient standalone resveratrol supplements are built around, without any NAD+ or CD38 component alongside it.
Polyphenol Defense: Vinomerix Optima® (OPCs)
Vinomerix Optima® is a grape-derived polyphenol concentrate providing OPCs (oligomeric proanthocyanidins), a class of antioxidant compounds studied for vascular and cellular protection. CLADE pairs 210mg of it with Resveratrol 95 for a combined 510mg polyphenol dose, more coverage than either ingredient offers alone.
NAD+ Production
NAD+ drives over 500 enzymatic reactions. Levels decline roughly 50% between ages 40 and 60. NMN is the most direct precursor, converting to NAD+ in cells. Most standalone NMN products cost $45+/mo.
NAD+ Protection (The Gap Nobody Talks About)
Here is where your current stack almost certainly has a blind spot. CD38 is an enzyme that increases with age and destroys up to 90% of your cellular NAD+. Taking NMN without blocking CD38 is filling a leaking bucket. Apigenin (the active compound in Testosurge) is a researched CD38 inhibitor. No mainstream competitor includes this ingredient, and it is rarely sold as a standalone consumer product at all.
Foundation (Mineral and Vitamin Cofactors)
Magnesium is required for mitochondrial ATP production. Zinc is an enzymatic cofactor. Methyl folate and B12 are foundation nutrients that support the NAD+ and polyphenol ingredients above. Without them, the specialized ingredients work at reduced capacity.
Most longevity supplements address one mechanism. The most comprehensive competitors cover two or three ingredients. Few combine NAD+ support and polyphenol antioxidant defense with CD38 protection in a single protocol.
What Your Current Longevity Supplement Stack Actually Costs
| Supplement | Monthly Cost | Mechanism Covered | What It Misses |
|---|---|---|---|
| Standalone NMN (various brands) | $45/mo | NAD+ Production (partial) | CD38 protection + polyphenol defense |
| Standalone Resveratrol (various brands) | $30/mo | Polyphenol antioxidant defense | NAD+ production + CD38 protection |
| Grape Seed / OPC Extract (various brands) | $15/mo | Polyphenol antioxidant defense | NAD+ production + CD38 protection |
| Standalone Apigenin / CD38 Blocker | Rarely sold standalone | CD38 protection | NAD+ production + polyphenol defense |
| Magnesium + Zinc + Methyl Folate + B12 | $32/mo | Foundation | Specialized actives |
| Total (4 separate bottles) | $122/mo at mid-market prices | Partial, uncoordinated | CD38 protection + coordinated dosing |
At mid-market prices those four bottles add up to about $122 per month. Buy the premium brands and it runs well past that. Zero CD38 protection unless you specifically source an apigenin product. A dozen or more capsules a day from four different brands.
The apigenin CD38-blocker dose? Rarely sold as a standalone consumer product at all, which is why most longevity stacks never cover this mechanism.
The NMN you are taking? Without a CD38 blocker, published research suggests up to 90% of the NAD+ it produces gets destroyed by the CD38 enzyme before reaching your cells. You are paying $45/mo for what may be 10% efficiency.
This is not a criticism of those products individually. Timeline's urolithin A research is legitimate. NMN precursor science is sound. The problem is structural: buying ingredient-by-ingredient from single-ingredient brands means you pay premium prices for incomplete coverage and zero coordinated dosing.
Now that you see what your current stack covers and where the gaps are, here is the protocol designed to close them.
See How One Protocol Covers NAD+ and Polyphenol Support
View the Full Protocol BreakdownOne Protocol. NAD+ and Polyphenol Support. $79/mo.
CLADE Longevity Complex was built for the person who has already done the research and reached the same conclusion: covering NAD+ support and polyphenol antioxidant defense with coordinated dosing in one protocol is better than juggling four bottles that leave gaps.
Here is what each capsule contains (3 capsules per day, 984mg of active ingredients, doses printed on the label):
Every single dose is printed on the label. No proprietary blends. You can look up each ingredient, verify the amount against published research, and confirm it matches clinical protocols. This is what CLADE means by "Know What You Take."
"I Dropped Four Supplements Down to One. Simpler than my old stack and covers more ground."
Verified Customer, 4.8 stars from 863 reviews
What Changes When NAD+ and Polyphenol Support Are Active
"HRV up 12 points. Energy is consistent all day now. Afternoon brain fog vanished."
David K., Age 54, Verified Buyer
The 90-day plan ($65/mo) is designed around this biology. Three months gives NAD+ support and polyphenol antioxidant defense time to produce measurable, trackable results.
You have seen the ingredient comparison, the cost math, and the results timeline. Here is how to start.
863 People Made the Switch. Here Is What They Report.
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The Questions Smart Buyers Ask First
- 90-day money-back guarantee (quarterly plan)
- 30-day money-back guarantee (monthly plan)
- No restocking fees
- Instant refunds
- Free US shipping on all subscriptions
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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*