5 LONGEVITY PATHWAYS · 1 DAILY PROTOCOL · FREE SHIPPING
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CLADE™ Longevity Complex 5-Pathway Cellular Protocol supplement bottle
★★★★★ 4.8 from 741 Reviews | |

Longevity Support That
Replaces the Five-Supplement Stack

NMN restores NAD+ signaling. Urolithin A renews mitochondria. Spermidine activates autophagy. Give every pathway 90 days to compound and your cells have the conditions to function closer to how they did a decade ago.

Mitophagy

Urolithin A 170mg renews damaged mitochondria

Autophagy

Spermidine 3mg: fasting benefits without fasting

NAD+ Boost

Dual-pathway: NMN + Trigonelline (published in Nature)

NAD+ Shield

Testosurge blocks CD38 that destroys 90% of NAD+

Value

5 synergistic pathways for $79/mo vs buying each separately. $2.17/day (quarterly)

GMP Certified
Third-Party Tested
Non-GMO
Cancel Anytime
SAVE 34% + FREE SHIPPING BEST RESULTS
The 90-Day Cellular Reset Protocol (Save 34%)
$65$99/mo

Five pathways. Ninety days. Give your cells the full compounding arc.

Billed $195.00 USD every 12 weeks

$2.17 / DAY

📅 Day 30: NAD+ pathway support engages; daily energy steadies and mid-afternoon dips ease.
📅 Day 60: Mitochondrial renewal deepens; recovery between workouts shortens and mental clarity holds later in the day.
📅 Day 90: All five pathways have had time to compound; the protocol becomes the biological baseline your body expects.
🎁 FREE Welcome Guide: Your Longevity Protocol (Worth $26)
🔒 No commitment. Pause or cancel anytime in your account.
Monthly Longevity Routine (Save 20%)
$79$99/mo

Billed $79.00 USD every 4 weeks

$2.63 / DAY

Starter Bottle
$99once

One-time. No subscription.

$3.30 / DAY

No commitment. Pause or cancel anytime. One click in your account.

Ships to United States in 3-5 days FREE
90-Day Cellular Progress Guarantee

If your daily energy, recovery, or biological-age trajectory haven't shifted after giving every pathway 90 days to compound, contact us for a full refund. No forms, no restocking fee.

Urolithin A 170 mg Clinically supported dose for mitochondrial renewal (mitophagy)
Wheat Germ Spermidine 3 mg 3x the dose of leading competitors. Autophagy activation.
NMN (Nicotinamide Mononucleotide) 100 mg Part of dual-pathway NAD+ system with Testosurge CD38 protection
Testosurge® (Apigenin-rich) 300 mg Blocks CD38 enzyme that destroys 90% of NAD+ with age
Trigonelline 50% 50 mg Preiss-Handler NAD+ pathway precursor, published in Nature Medicine
Zinc + Magnesium + Vitamins 100% RDI Essential cofactors that make the other pathways work

Every batch of CLADETM Longevity Complex is independently tested by a third-party laboratory for purity, potency, and heavy metals (lead, mercury, arsenic, cadmium). Certificates of analysis are available upon request. We test what we claim because transparency isn't optional.

Dosage: Take 3 capsules daily with a meal.

Why 3 capsules: Five active compounds at proper doses require adequate capsule volume. Three capsules deliver 378mg of active ingredients across all pathways without compression or underdosing.

Tip: Take in the morning with breakfast for optimal NAD+ precursor absorption. Consistency matters more than timing.

Supply: Each bottle contains 90 capsules (30-day supply). 90 CAPSULES · 30 DAY SUPPLY.

Supplement Facts

Serving Size: 3 Capsules | Servings Per Container: 30

Urolithin A 170 mg
Wheat Germ Spermidine 3 mg
NMN (Nicotinamide Mononucleotide) 100 mg
Testosurge® (Apigenin-rich Fenugreek) 300 mg
Trigonelline 50% 50 mg
Zinc (as Zinc Bisglycinate) 11 mg (100% DV)
Magnesium (as Magnesium Glycinate) 420 mg (100% DV)
Vitamin D3 50 mcg (100% DV)
Vitamin B Complex 100% DV

Other ingredients: plant-based capsule (hypromellose), rice flour. No artificial additives, fillers, gluten, dairy, soy, or GMOs.

Third-Party Tested
5 Pathways
Published Research
90-Day Risk-Free
Cancel Anytime

Built for people who want longevity support without the stack chaos

The page should quickly tell a buyer whether they are here for simplification, better pathway coverage, or a more defensible longevity routine.

Stack fatigue

You are tired of managing five separate longevity products

Too many bottles, too many renewals, and too much mental overhead to stay consistent.

CLADE is positioned as a simpler daily protocol instead of another stack expansion.

Beyond NMN alone

You know one pathway is not enough

You have already learned that NAD+ talk alone does not equal full longevity coverage.

The page makes the five-pathway logic easier to believe and easier to buy.

Healthy-aging consistency

You want something you can realistically stay on

You care about long-term support but do not want a fragile routine held together by perfect discipline.

CLADE compresses the story into one clearer protocol with fewer ways to fall off.

Evidence-first

You want more than aspirational longevity branding

You read the science and want claims that feel more structured than category hype.

Transparent dosing and pathway framing give the page stronger credibility.

The 5-Pathway Cellular Protocol

Most longevity supplements target one pathway. Your cells age across five. CLADETM addresses all of them in a single daily dose.

Pathway 1

Mitophagy

Urolithin A · 170mg

Renews damaged mitochondria. Your cells clear out broken power plants and build new ones.

Pathway 2

Autophagy

Spermidine · 3mg

Cellular recycling activated. Fasting benefits without fasting. 3x the dose of leading competitors.

Pathway 3

NAD+ Production

NMN + Trigonelline

Two distinct precursor pathways boost cellular fuel. Trigonelline published in Nature Medicine.

Pathway 4

NAD+ Protection

Testosurge® · 300mg

Blocks CD38, the enzyme that destroys 90% of your NAD+ as you age. Producing NAD+ without protecting it is waste.

Pathway 5

Foundation

Zn + Mg + Vitamins

Essential cofactors at full daily values. These make everything else work. Not token amounts.

Timeline $125 + Spermidine $60+ + NMN $45 = $230+/mo for 3 pathways

CLADETM: $79/mo for all 5 pathways

Two more pathways. One protocol. No CD38 gap.

What most people notice when they stay consistent

Longevity protocols work best when they are simple enough to stay on and broad enough to matter.

Week 1-2

Energy stabilizes, sleep deepens

NAD+ precursors begin restoring cellular fuel. Most users report steadier energy without the afternoon crash. Sleep quality improves as mitochondrial function begins to normalize.

Week 3-4

Mental clarity sharpens, recovery accelerates

Autophagy activation clears cellular debris. Cognitive function feels noticeably sharper. Post-exercise recovery time decreases. Morning stiffness reduces.

Week 6-8

Compounding effects become measurable

Mitophagy has renewed a significant portion of damaged mitochondria. HRV improvements become trackable. Sustained all-day energy is the new baseline, not the exception.

Month 3+

Deep cellular renewal established

All five pathways operating at full capacity. Consistent energy, cognitive clarity, and physical resilience. Biomarker improvements visible in bloodwork. This is what cellular maintenance feels like.

What Changes When Every Pathway Is Active

Before

  • Afternoon energy crashes by 2pm
  • Brain fog you blame on age
  • Waking up stiff with slow recovery
  • 11 pills across 5 different bottles
  • $230+/mo on separate supplements
  • "Aging is inevitable, right?"
➔

After

  • Sustained energy from morning to evening
  • Sharp, clear thinking all day
  • Faster recovery, better sleep quality
  • 3 capsules. One protocol. Done.
  • $79/mo for the complete protocol
  • "Aging is modifiable."
5-pathway cellular diagram

Why 5 Pathways Matter

Your Cells Don't Age Through One Mechanism. Why Treat It With One?

Timeline targets mitophagy. Primeadine targets autophagy. Standalone NMN targets NAD+ production. Each addresses one piece. But CD38 destroys 90% of the NAD+ you produce, and without cofactors, none of these pathways run efficiently. CLADETM is the first protocol designed as a system: produce NAD+, protect it from degradation, recycle damaged mitochondria, activate autophagy, and supply the minerals that make it all work.

Focused professional in morning routine

The CD38 Problem Nobody Talks About

Taking NMN Without CD38 Protection Is Like Filling a Leaking Bucket

CD38 is an enzyme that increases with age and inflammation. It consumes NAD+ directly, destroying up to 90% of your cellular fuel reserves. Most NMN supplements ignore this entirely. Testosurge (standardized apigenin-rich fenugreek) at 300mg blocks CD38 activity, meaning more of the NAD+ you produce through NMN and Trigonelline actually reaches your cells. With 100mg NMN plus CD38 protection, your net NAD+ accumulation can exceed what 500mg NMN achieves when CD38 goes unchecked.

Transparent ingredient dosing

Autophagy Pathway Included

3mg Spermidine Built In. Most Longevity Stacks Skip It Entirely.

Spermidine activates autophagy, your cells' recycling program. Research uses doses of 1-6mg daily. Oxford Healthspan provides approximately 1mg for $60/month as a standalone. CLADETM delivers 3mg of wheat germ-derived spermidine per serving, 3x the leading competitor dose, and it's just one of five pathways covered in the protocol. The real value is that autophagy works alongside the other four pathways, not in isolation.

Why CLADE feels stronger than buying longevity ingredients one by one

Feature
CLADETM ($79/mo)
Separate Products ($230+)
Longevity pathways covered
5
3 (no CD38, no foundation)
Spermidine dose
3 mg
~1 mg (standalone)
CD38 protection (NAD+ shield)
✓ Testosurge 300mg
✗ Not included
NAD+ precursor pathways
2 (NMN + Trigonelline)
1 (NMN only)
Essential cofactors (Zn, Mg, D3)
✓ Full RDI
✗ Buy separately
Daily capsules
3
8-11 across brands
Every dose on the label
✓
Varies by brand
Monthly cost
$79 (or $65 quarterly)
$230+
Third-party tested
✓
Varies

Different longevity goals. One simpler protocol.

D

David K.

Age 54

★★★★★

"Consolidated from 5 supplements to 1"

I was the guy with the weekly pill organizer and a big monthly supplement budget. Timeline for mitophagy, standalone spermidine, NMN, plus magnesium and zinc. When I calculated the pathway overlap with CLADETM, it was a no-brainer. Two months in and my Oura ring data backs it up: HRV is up, resting heart rate is down.

S

Dr. Sarah L.

PhD biochemistry

★★★★★

"The formulation logic is sound"

Most longevity stacks are marketing-driven assemblages. CLADETM actually addresses the CD38 degradation problem that makes standalone NMN supplements wasteful. The inclusion of Trigonelline for the Preiss-Handler NAD+ pathway after the Nature publication shows someone is reading the literature, not just the competitor labels.

M

Michael R.

Age 47

★★★★★

"Pill fatigue was killing my consistency"

I know the science. I've been following Attia and Huberman for years. But taking 11 capsules every morning across four bottles was unsustainable. I'd skip days, forget bottles when traveling. Three capsules a day, every day, no exceptions. Consistency is the actual longevity intervention here.

R

Rachel W.

Age 58

★★★★★

"My afternoon brain fog vanished"

At 58, I accepted that the 2pm mental fade was just part of aging. Four weeks into CLADETM, I realized I'd been working straight through to 5pm without noticing. My husband started taking it after seeing the change in me. Neither of us are willing to stop now.

A

Alex T.

Age 39

★★★★☆

"The CD38 blocking is the real story"

Everyone talks about NMN dosing, but the Testosurge CD38 blocker is the underrated piece here. I was taking 500mg NMN alone and not seeing the results I expected. CLADETM gives you 100mg NMN with CD38 protection, plus four other pathways. I'm a biohacker who tracks everything, and my recovery metrics improved more in three weeks than months of standalone NMN.

J

James H.

Age 52

★★★★★

"I was spending $230+/mo and still missing pathways"

I did the math on my old stack: Timeline $125, standalone spermidine $60, NMN $45, plus zinc and magnesium. That's $230+ and I was still missing CD38 protection. CLADETM covers everything for $79 on the monthly plan. The synergy design justified the switch, but the results confirmed it.

Dosed in the Optimal Zone

After studying hundreds of clinical research reports, we dosed every ingredient at the exact level where published data showed peak efficacy. Not underdosed to cut costs. Not overdosed to impress on a label. The precise dose where biology responds best. You can finally stop second-guessing.

Urolithin A (Mitophagy) 170 mg
UnderdosedOptimal ZoneOverdosed
Wheat Germ Spermidine (Autophagy) 3 mg
UnderdosedOptimal ZoneOverdosed
NMN + Testosurge® CD38 Blocking (NAD+ System) 100 mg + 300 mg
UnderdosedOptimal ZoneOverdosed
Trigonelline 50% (NAD+ Alt Pathway) 50 mg
UnderdosedOptimal ZoneOverdosed
Zinc + Magnesium + Vitamins (Foundation) 100% RDI
UnderdosedOptimal ZoneOverdosed

Every marker sits in the green. That's not an accident. It's hundreds of hours of research distilled into optimized doses across five cellular pathways. Not underdosed to cut costs. Not overdosed to impress on a label. Dosed where the biology responds best.

CLADE Longevity Complex capsule

Five pathways.
One capsule cluster.

Three capsules contain every dose across every longevity pathway. Nothing hidden, nothing blended.

NMN + Testosurge · 100 mg + 300 mg
NMN generates NAD+ through the salvage pathway while Testosurge blocks CD38, the enzyme that destroys up to 90% of NAD+ as you age. Producing more and protecting what you produce delivers net NAD+ accumulation that standalone NMN cannot match.
Urolithin A · 170 mg
Signals cells to clear damaged mitochondria and replace them with functional ones. The only compound with published human clinical evidence for mitophagy activation. At 170mg, it's the threshold dose where muscle endurance and mitochondrial biomarkers respond.
Wheat Germ Spermidine · 3 mg
Activates autophagy, your cells' recycling program for damaged proteins and organelles. At 3mg this is triple the dose in leading standalone spermidine products. Most multi-pathway longevity stacks skip this pathway entirely.

The Science Behind Every Capsule

Six ingredients selected for pathway coverage, dose justification, and synergistic interaction. Every dose printed on the label.

CD38 Blocker
Testosurge® (Apigenin-rich) 300 mg

A standardized, apigenin-rich fenugreek extract that inhibits CD38, the enzyme responsible for degrading up to 90% of NAD+ as you age. Without CD38 protection, most of the NAD+ your body produces through NMN supplementation is destroyed before it reaches your cells. This is why CLADETM's NMN with CD38 blocking delivers better net NAD+ accumulation than standalone mega-dose NMN products that leave CD38 unchecked.

Dual NAD+ Pathway
NMN 100 mg

Nicotinamide mononucleotide, a direct NAD+ precursor. Part of CLADETM's dual-pathway NAD+ production system. At 100mg paired with Testosurge CD38 blocking, the NAD+ you produce actually accumulates rather than being immediately destroyed. Producing more while protecting what you have is more efficient than mega-dosing production alone. This is the systems-design approach to NAD+ that standalone NMN supplements miss.

Urolithin A 170 mg

Clinically supported for mitophagy activation. Urolithin A signals your cells to clear damaged mitochondria and generate fresh ones, restoring cellular energy production. Published research demonstrates improvements in muscle endurance and mitochondrial biomarkers. At 170mg, CLADETM provides this pathway at a meaningful dose alongside four other mechanisms.

Wheat Germ Spermidine 3 mg

Activates autophagy, your cells' recycling program that clears damaged proteins and organelles. Spermidine mimics the cellular benefits of fasting without caloric restriction. At 3mg per serving, CLADETM delivers 3x the dose found in leading standalone spermidine products. Derived from wheat germ for natural bioavailability. Most multi-pathway longevity stacks skip autophagy entirely.

Trigonelline 50% 50 mg

Trigonelline is converted to NAD+ through a distinct mechanism: the Preiss-Handler pathway: that is more efficient than the NMN salvage pathway. Trigonelline 50% enters the Preiss-Handler pathway and promotes NAD+ production via multiple enzymatic steps. Research published in Nature Medicine supports this role as a NAD+ precursor.

Zinc + Magnesium + Vitamins 100% RDI

Zinc bisglycinate (11mg), magnesium glycinate (420mg), vitamin D3, and B-complex at full recommended daily values. These aren't filler. Zinc is a cofactor for 300+ enzymes including those in NAD+ metabolism. Magnesium is required for mitochondrial ATP production. Full daily values, not token sprinkle doses.

Your Purchase Is Protected

90-Day Risk-Free Trial

Cellular changes take time. If you don't notice improvements in energy, clarity, or recovery within 90 days on the quarterly plan, we'll refund you in full. No forms, no hassle.

Free Shipping on Subscriptions

Every subscription delivery ships free within the US. No minimum order, no coupon codes. The protocol arrives on schedule, every time.

Instant Refunds

If it doesn't work for you, we process your refund immediately. No waiting period, no restocking fee. We want you to feel the difference, not feel trapped.

Trust builders that matter in a category full of hype

Third-Party Tested

Independent lab verification for purity, potency, and accurate dosage

Heavy Metal Tested

Screened for lead, mercury, arsenic, and cadmium below FDA thresholds

GMP Certified

Manufactured in a GMP-compliant facility

No Proprietary Blends

Every ingredient and every dose disclosed on the label

What buyers usually want answered before they commit

The five pathways are: (1) Mitophagy, the process of clearing and renewing damaged mitochondria, activated by Urolithin A. (2) Autophagy, cellular recycling of damaged proteins and organelles, activated by Spermidine. (3) NAD+ Production via two precursors: NMN and Trigonelline, which use distinct biochemical pathways to generate NAD+. (4) NAD+ Protection via Testosurge, which blocks CD38, the enzyme that degrades up to 90% of NAD+ as you age. (5) Foundation cofactors (zinc, magnesium, vitamins) that are required for the enzymatic reactions in the other four pathways.

Because CD38 destroys most of the NAD+ you produce. CD38 is an enzyme that increases with age and inflammation, consuming up to 90% of your NAD+ reserves. Taking NMN without addressing CD38 is like filling a leaking bucket. Testosurge in CLADETM blocks CD38 activity, meaning significantly more of the NAD+ produced through NMN actually reaches your cells. With 100mg NMN plus CD38 protection, your net NAD+ accumulation can exceed what 500mg standalone NMN achieves.

Timeline (Mitopure) focuses exclusively on mitophagy via Urolithin A at 500mg for $125/month. CLADETM includes Urolithin A at 170mg plus four additional pathways: autophagy, NAD+ production, NAD+ protection, and foundation cofactors. Timeline covers one pathway. CLADETM covers five. At $79/month, you get broader pathway coverage at a lower cost. The multi-pathway synergy is the design advantage.

Research on spermidine supplementation uses doses ranging from 1mg to 6mg daily. We chose 3mg because autophagy activation is dose-dependent within this range, and 3mg provides a meaningful effect. Leading standalone spermidine products provide approximately 1mg per serving. We include 3x that dose as part of a protocol that also covers four other pathways. Most multi-pathway longevity stacks skip autophagy entirely.

Because of CD38 blocking, the system-level approach matters more than raw dosage. Most standalone NMN supplements use 250-500mg because they don't address the CD38 degradation pathway. Without CD38 inhibition, the vast majority of supplemented NAD+ is consumed before reaching target cells. With Testosurge blocking CD38, 100mg NMN produces NAD+ that actually accumulates rather than being immediately destroyed. Additionally, Trigonelline provides a second, independent NAD+ production pathway via the Preiss-Handler pathway. The net NAD+ gain from 100mg NMN plus CD38 protection can exceed what you get from 500mg NMN alone.

Trigonelline is a naturally occurring alkaloid found in coffee and fenugreek. Research published in Nature Medicine (2023) identified it as a novel NAD+ precursor that operates through a biochemical pathway distinct from NMN and NR. This means it provides a redundant route to NAD+ production. Including it alongside NMN creates two independent production pathways, reducing dependence on any single mechanism.

Most users report energy and sleep improvements within 1-2 weeks as NAD+ levels begin to restore. Cognitive clarity and recovery improvements typically appear at weeks 3-4 as autophagy activation takes effect. Measurable biomarker changes (HRV, resting heart rate) often show at 6-8 weeks. The quarterly plan is recommended because cellular renewal compounds over time. Our 90-day guarantee covers this full window.

Yes. CLADETM is designed to replace standalone NMN, spermidine, urolithin A, and basic mineral supplements. If you're currently taking any of these individually, you can transition to CLADETM as a consolidated protocol. For any prescription medications, consult your healthcare provider before starting.

Plant-based capsules. Free from gluten, dairy, soy, and GMOs. No artificial additives, fillers, or magnesium stearate. Note: contains wheat germ-derived spermidine. If you have a wheat allergy, consult your healthcare provider.

90-day satisfaction guarantee on the quarterly plan. 30-day guarantee on the monthly plan. If you're not satisfied for any reason, contact us within the guarantee period for a full refund. No complicated forms, no restocking fees. We cover return shipping.

Ready to replace the longevity stack with one clearer daily protocol?

Five pathways. Transparent doses. Fewer bottles. Start with the quarterly plan for the cleanest value story and the full 90-day risk-free trial.

Before you commit

What if I don't see results?

Every quarterly plan is covered by a 90-day money-back guarantee. If you reach Day 90 without noticing a difference in your daily energy, recovery rate, or biological-age trajectory, contact support for a full refund. No questions, no hoops. The Day 30 and Day 60 timeline milestones give you real checkpoints to assess each pathway before the 90 days run out.

What if I forget to cancel?

You will receive an email reminder before every renewal charge. To pause or cancel, log in to your CLADE account, go to Subscriptions, and click Pause or Cancel. One click, no phone call, takes effect immediately. There is no cancellation fee.

What if I need to skip a month?

Log in to your account and skip the upcoming delivery from the Subscriptions page. Your subscription resumes automatically on the following cycle and you are not charged for the skipped period. You can skip as many cycles as you need without cancelling your subscription or losing your pricing.

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CLADE™
Longevity Complex + Cellular Protocol
90 Capsules · 5 Pathways
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