Aging Isn't One Thing Going Wrong.
It's Two. Here's How to Address Both.
Your cells age on two fronts: declining NAD+ and rising oxidative stress. Most supplements only address one. A single daily protocol covers both. 741 people have already made the switch.
See the NAD+ and Polyphenol ProtocolThe afternoon brain fog that settles in around 2pm. The recovery from a Saturday hike that used to take a day and now takes three. The energy that was always there without thinking about it, until it wasn't.
You have tried the usual answers. More sleep. Better diet. A magnesium supplement someone recommended. Maybe a methyl folate and B12 combo. Each one helped a little, but none of them changed the overall trajectory.
Here is the part most people never hear from their doctor: aging is not one thing going wrong. It is two separate processes happening inside your cells at the same time. Your NAD+ production collapses (roughly 50% gone by age 50) while an enzyme called CD38 destroys up to 90% of what you do produce. At the same time, oxidative stress from decades of cellular wear builds up faster than your body can clear it. Addressing just one of those (which is what most supplements do) leaves the other unchecked.
That is why the supplements you have tried felt like they helped at first and then plateaued. They were working on one mechanism while the other continued to slide.
This is not about fighting aging. It is about giving your cells what they need to function the way they did ten years ago. NAD+ support and polyphenol antioxidant defense. One daily protocol. And a timeline for what you can realistically expect to feel.
Two Things Your Cells Need. Most Supplements Cover One.
Think of your cells like a house. You would not just rewire it and ignore the foundation cracking underneath. But that is exactly what single-ingredient supplements do: they hit one mechanism and leave the other to keep declining.
Here is what is actually happening, in plain language:
Defend: Quench Oxidative Stress at the Source
Decades of normal cell activity generate free radicals faster than your body can clear them. That oxidative load accumulates and wears down cellular function over time. Resveratrol 95 (300mg) is a well-studied polyphenol antioxidant that helps neutralize that load.
Neutralize: Reinforce Your Antioxidant Defenses
A single antioxidant can only do so much on its own. Layering a second, complementary polyphenol source broadens the range of free radicals your cells can clear. Vinomerix Optima® (210mg) delivers a concentrated dose of grape-derived OPCs that work alongside Resveratrol.
Energize: Restore Cellular Fuel Production
NAD+ is a molecule involved in over 500 reactions inside your cells. It is essential for converting food into energy. Levels drop roughly 50% by age 50. NMN (255 mg) and Trigonelline 50% (60 mg) are two precursors that help your body rebuild NAD+ levels through complementary pathways. NMN feeds the salvage pathway. Trigonelline is converted to NAD+ through a distinct mechanism, the Preiss-Handler pathway, that is more efficient than the NMN salvage pathway and published in Nature Medicine.
Protect: Stop the Enzyme That Wastes Your Fuel
Here is what makes the energy mechanism tricky. An enzyme called CD38 increases with age and can destroy up to 90% of the NAD+ your body produces before it ever reaches your cells. Taking an energy precursor without blocking this enzyme is like running a faucet into a bucket with a hole. Testosurge® (Apigenin-rich) (150 mg) is a clinically studied extract that inhibits CD38, so the NAD+ your body produces actually reaches your cells.
Support: The Foundation Everything Else Runs On
Magnesium, Zinc, Methyl Folate, and Vitamin B12 are not glamorous. But both mechanisms above depend on them. Magnesium alone is required for mitochondrial energy production. Without adequate foundation nutrients, the specialized ingredients work at reduced capacity. It is like buying premium fuel for a car with a weak battery.
Most supplements address one of these mechanisms. A few address both. Almost none combine NAD+ support with polyphenol antioxidant defense, and almost none include the CD38 protection above.
What Is in Your Daily Dose (984mg Across 3 Capsules)
| Mechanism | Ingredient | Daily Dose | What It Does |
|---|---|---|---|
| Defend | Resveratrol 95 | 300mg | Polyphenol antioxidant that helps neutralize oxidative stress |
| Neutralize | Vinomerix Optima® | 210mg | Grape-derived OPCs that reinforce antioxidant defense |
| Energize | NMN + Trigonelline 50% | 255 mg + 60 mg | Two mechanisms to support cellular energy (salvage + Preiss-Handler) |
| Protect | Testosurge® (Apigenin-rich) | 150 mg | Blocks the CD38 enzyme that wastes cellular energy before it reaches your cells |
| Support | Zinc + Magnesium + Methyl Folate + B12 | 100% RDI each | Essential mineral and vitamin foundation |
Now that you understand both mechanisms, here is how one protocol addresses them.
See How One Protocol Covers Both Mechanisms
View the Full Ingredient PanelWhat Actually Changes When Both Mechanisms Are Working
The question everyone asks: what does this feel like? Here is what 741 verified buyers consistently report.
Energy returns. Not the jittery kind from caffeine. The steady, all-day kind you used to have without thinking about it. The 2pm fog lifts. You finish the day with reserves instead of running on empty.
Mental clarity sharpens. The word-finding pauses decrease. Focus holds for longer stretches. Reading comprehension that felt like it was slipping comes back. Several reviewers describe it as "the lights coming back on."
Recovery accelerates. Weekend activities no longer require weekday recovery. Muscle soreness resolves faster. Morning stiffness that had become normal starts to feel like it belongs to someone else.
Sleep deepens. Not just falling asleep faster, but the kind of sleep where you wake up and actually feel rested. Multiple reviewers mention dreaming again for the first time in years.
These are not separate benefits from separate ingredients. They are downstream effects of two cellular mechanisms working in concert for the first time.
"My husband noticed before I did. He said I seemed sharper, more present. That was week three."
Eleanor K., Age 59, Verified Buyer
What to Expect, Week by Week
Your cells did not slow down overnight. They will not come back overnight either. But the progression follows a consistent pattern across hundreds of reviews.
The 90-day plan is $65/mo. The monthly plan is $79/mo. Both include free shipping and a full money-back guarantee.
One Protocol Covers Two Mechanisms in One Bottle
| What You Get | Buying Separately | CLADE™ Protocol |
|---|---|---|
| Monthly cost | More, across multiple subscriptions and bottles | $79/mo (or $65 on 90-day plan) |
| Cellular mechanisms covered | Usually just 1 | Both |
| Daily capsules | 8-12 from different bottles | 3 capsules, one bottle |
| CD38 enzyme protection | Not available | Included (Testosurge® 150 mg) |
| Brands to manage | 3-5 subscriptions | 1 |
| Dose transparency | Varies, some use proprietary blends | Every dose printed on label |
You have been paying more to get less. Not because those individual products are bad, but because covering just one mechanism while the other keeps declining is an incomplete strategy. CLADETM was designed to close both gaps in one protocol, at a fraction of the combined cost.
You have seen both mechanisms, what changes, and the timeline. Here is how to start.
741 Verified Buyers. 4.8 Stars. See What They Report.
Feel Like Yourself Again - $65/moFree US Shipping. 90-Day Money-Back Guarantee.
What People Like You Are Saying
"I told my husband I feel like the version of myself from five years ago. The energy, the sleep, the mental sharpness. He started taking it too after watching me for a month."
Verified Buyer"My doctor noticed my inflammation markers improved at my 6-month checkup. When I told him it was a supplement, he asked to see the label. He said the doses were legitimate."
Verified Buyer"As a physician, I evaluate supplements differently than most consumers. The dual NAD+ and polyphenol approach tracks with current geroscience literature. I have been taking it myself for four months."
Physician"I was the guy who thought supplements were a waste of money. My wife convinced me to try this for 90 days. By month two, I was sleeping through the night and keeping up with my kids on the weekends. I am a believer now."
Verified BuyerCommon Questions
- 90-day money-back guarantee (quarterly plan)
- 30-day money-back guarantee (monthly plan)
- No restocking fees
- Free US shipping on all plans
- Cancel anytime
Feel Like Yourself Again.
Start the NAD+ and Polyphenol Protocol - $65/moFree US Shipping. 90-Day Guarantee. Cancel Anytime.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*